Publications

  1. Menendez, L, Trecek, T, Gopalakrishnan, S, Tao, L, Markowitz, AL, Yu, HV et al.. Generation of inner ear hair cells by direct lineage conversion of primary somatic cells. Elife. 2020;9 :. doi: 10.7554/eLife.55249. PubMed PMID:32602462 PubMed Central PMC7326493.
  2. Gnedeva, K, Wang, X, McGovern, MM, Barton, M, Tao, L, Trecek, T et al.. Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal. Proc. Natl. Acad. Sci. U.S.A. 2020;117 (24):13552-13561. doi: 10.1073/pnas.2000175117. PubMed PMID:32482884 PubMed Central PMC7306825.
  3. Jen, HI, Hill, MC, Tao, L, Sheng, K, Cao, W, Zhang, H et al.. Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1. Elife. 2019;8 :. doi: 10.7554/eLife.44328. PubMed PMID:31033441 PubMed Central PMC6504235.
  4. Gnedeva, K, Hudspeth, AJ, Segil, N. Three-dimensional Organotypic Cultures of Vestibular and Auditory Sensory Organs. J Vis Exp. 2018; (136):. doi: 10.3791/57527. PubMed PMID:29912206 PubMed Central PMC6101446.
  5. Semerci, F, Choi, WT, Bajic, A, Thakkar, A, Encinas, JM, Depreux, F et al.. Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance. Elife. 2017;6 :. doi: 10.7554/eLife.24660. PubMed PMID:28699891 PubMed Central PMC5531831.
  6. Teng, CS, Yen, HY, Barske, L, Smith, B, Llamas, J, Segil, N et al.. Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle ear. Sci Rep. 2017;7 (1):2497. doi: 10.1038/s41598-017-02574-7. PubMed PMID:28566723 PubMed Central PMC5451394.
  7. Basch, ML, Brown, RM 2nd, Jen, HI, Semerci, F, Depreux, F, Edlund, RK et al.. Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates. Elife. 2016;5 :. doi: 10.7554/eLife.19921. PubMed PMID:27966429 PubMed Central PMC5215100.
  8. Stojanova, ZP, Kwan, T, Segil, N. Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea. Development. 2016;143 (9):1632. doi: 10.1242/dev.137976. PubMed PMID:27143757 PubMed Central PMC4986168.
  9. Rainey, RN, Ng, SY, Llamas, J, van der Horst, GT, Segil, N. Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice. J. Neurosci. 2016;36 (17):4758-70. doi: 10.1523/JNEUROSCI.3890-15.2016. PubMed PMID:27122034 PubMed Central PMC4846672.
  10. Abdolazimi, Y, Stojanova, Z, Segil, N. Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter. Development. 2016;143 (5):841-50. doi: 10.1242/dev.129320. PubMed PMID:26932672 PubMed Central PMC4813338.