Disease modeling, stem cells and cellular reprogramming in the auditory system
Neil Segil, Justin Ichida, Taka Ohyama and Radha Kalluri
This new project involves direct reprogramming of differentiated cells to the sensory lineage, with the goal of developing cellular models of inner ear disease. The new techniques for reprogramming skin cells into induced pluripotent stem cells (iPSCs), as well as directly into differentiated elements of the auditory system, will allow the development of in vitro models of disease. There is currently a graduate student project available to help characterize the neurophysiological state of cells following cellular reprogramming. This project is funded by the new Regenerative Medicine Initiative, sponsored by the Keck School of Medicine of USC, Dean Carmen Puliafito and the Department of Regenerative Medicine and Stem Cell Biology.