Key mutations may worsen hearing loss from the chemotherapy drug cisplatin
Posted May. 17, 2016, at 4:59pm
The chemotherapy drug cisplatin can kill cancer, but it can also kill the sensory cells of the inner ear — causing permanent hearing loss. This hearing loss is likely to be more severe in individuals with Cockayne syndrome, according to a new study on the cover of The Journal of Neuroscience.
In the study, USC Stem Cell researchers Robert N. Rainey and Sum-yan Ng from the laboratory of Neil Segil demonstrated that cisplatin causes more acute hearing loss in mice with the equivalent of Cockayne syndrome.