University of Southern California

Segil Lab

USC Stem Cell

Key mutations may worsen hearing loss from the chemotherapy drug cisplatin

zns017160000C1The chemotherapy drug cisplatin can kill cancer, but it can also kill the sensory cells of the inner ear — causing permanent hearing loss. This hearing loss is likely to be more severe in individuals with Cockayne syndrome, according to a new study on the cover of The Journal of Neuroscience.

In the study, USC Stem Cell researchers Robert N. Rainey and Sum-yan Ng from the laboratory of Neil Segil demonstrated that cisplatin causes more acute hearing loss in mice with the equivalent of Cockayne syndrome.

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