Sensory regeneration and inner ear biology
Hearing loss and balance disorders affect more than half of all adults in the U.S. by the time they reach retirement age. The death of sensory hair cells in the inner ear and their failure to regenerate are the major cause of deafness. The long-term goal of our laboratory is the treatment of deafness through regeneration of these sensory hair cells. Our current research is on the developmental processes that shape the complex structures of the inner ear, in particular, the mechanisms that control cell division and cell fate during embryonic development. We also study the homeostatic mechanisms that allow for the lifelong survival of hair cells, as well as the particular sensitivity of these cells to environmental stress from noise, certain antibiotics and chemotherapy agents, and how this relates to the cell cycle, DNA damage and repair.
- Neil Segil hosts 360 video tour of USC’s stem cell research center May 16, 2018
- Louise Menendez receives Travel Award April 9, 2018
- Ksenia Gnedeva receives a new NIDCD R21 award April 9, 2018